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Name: Laura Alexander
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Question:
I am part of a research group studying different chemicals and their effects on animals and, plants, and humans. Our chemical is dinitrophenol (C14 H2 0 N2 O5). My research group and I would like to know if there are any serious side effects to exposure to this chemical, and if so, what are they? Also, is this a well-known chemical and have there been any cases of it being exposed to harmfully or exposed to humans, plants or animals?



Replies:
Here are some research reports to look for in your library, or contact the National Technical information Service or Superintendent of Documents at the US Government Printing Office:

1990 "Toxicological Profile for Phenol" by Agency for Toxic Substances and Disease Registry

1986 "Summary Review of the Health Effects of Phenol" by US Environmental Protection Agency

1980 "Bioassay of Phenol for Possible Carcinogenicity" by National Institutes of Health Carcinogenesis Testing Program

1976 "Occupational Exposure to Phenol: Criteria for a Recommended Standard" by National Institute of Occupational Safety and Health.

Mortis


Update -- 2002
I recently read a question asked about Dinitrophenol (DNP) on your web site. I am a physician and I have recently seen a number of events in which teenagers have taken DNP to loose weight and to build muscle. Consequently, a number of them have died. DNP is a strong uncoupler of oxidative phosphorylation for which there is not immediate treatment. These children burn up from the inside out. Please be sure your young readers are aware of these dangers. Thank you for your assistance in this matter. Lisa D. M.D.



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