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Name: Raveed
Status: Student
Grade:  Other
Location: Outside U.S.
Country: Pakistan
Date: January 2009

How does the homologous chromosomes recognize each other in Meisosi I pairings?

That is a great question. The research is showing that each chromosome unzips a small region of its DNA and they bind together there because of opposite base pairing. There seem to be enzymes that coordinate this process.


My guess would be by base pairing between the sense strand of one chromosome and the anti-sense strand of the homologous chromosome. This assumes that the strands of each of the homologous chromosomes unwind and are available for Hydrogen bonding to a complementary strand using the Watson-Crick rules for base pairing (A-T & G-C). This base pairing between complementary strands of homologous chromosomes is probably the physical basis for crossing-over between homologous chromosomes.

Ron Baker, Ph.D.

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