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Name: Stereo
Status: Other
Grade:  Other
Location: N/A
Country: United States
Date: March 2007


Question:
If the genes for differentiation of cells (which have been switched off at time of birth or even before it) are switched on after 20 years of age can regeneration takes place in a man with one arm to replace a second one?



Replies:
There's a lot of research going on right now to try to figure out if this is theoretically possible. Most scientists think it *is* theoretically possible (although not all). But theory and practice are very different things.

It's an extremely complex thing to set up all the necessary genes (thousands) and chemical signals to coax cells to form anything -- let alone something like an arm. We have trouble getting cells to just live, let alone differentiate into complex structures.

While it might be theoretically possible, right now we are very, very far away from actually being able to grow a new arm.

Burr


Regeneration science is in its infancy. To build an arm requires a lot of coordination and synchronization between tissues and other major organ development; such as the torso and muscles that will be attached elsewhere in order for the arm to move. The agents of this development is the so called "Hox" genes. These genes are the planners and executors for major area development and are in control at the earliest stage of development. In human development, these genes work with others to develop the whole organism and it seems that we have an issue when it comes to just growing an arm when the rest of the body is totally developed. This will lead to a lack of the necessary feedback mechanisms for the specific hox genes to operate. We may be able to mediate this problem in the future, but right now we are not close to understanding how this can be realized.

Steve Sample


In view of the fact that differentiated mammalian cells (e.g. mammary and skin cells) have been used to clone sheep, cows, dogs and cats, it would appear that any cell might have the ability to de-differentiate and then re-differentiate. Based on this, I would say that it's theoretically possible to regenerate a human limb.

Ron Baker, Ph.D.



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