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Name: Robert
Status: Other
Grade:  Other
Location: WI
Country: United States
Date: September 2006
Question:
How does damage to mitochondria DNA result in apoptosis, given the understanding of the intrinsic pathway of apoptosis? Any ideas? Would there be a good person I could ask this question too?


Replies:
I only know that changes in Ca++ concentration in the cytosol, causes cytochrome C to leak out of mitochondria which in turn activates a protease that degrades proteins. If you do a search on google under "mitochondrial apoptosis" you will get over 3 million hits.

Ron Baker, Ph.D


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