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Name: James B.
Status: Educator
Age: 60s
Location: N/A
Country: N/A
Date: June 2003


Question:
Your experts say it is not possible to identify race from DNA, yet two articles in the New England Journal of Medicine in March 2003 and an article in the New York Times relating to DNA tests used to narrow suspects in a criminal case in Louisiana (NY Times, 6/3/2003) seem to call this into question. Any response from your experts?



Replies:
It was not possible before the draft of the Human Genome was released. We have much more information than before and the databases are being updated daily. It may be possible in the future to identify a number of attributes via DNA.

vanhoeck


I am not the genetics expert; however, I am a student of "scientific methodology" and the sources cited here are excellent examples of how it is (not) applied. Consider the references in NEJM. The two articles are not peer reviewed research papers, but appear in the "Perspectives" section of the journal, which is a give-and-take section where different positions and contrasting views on controversial topics are put forth -- These do not have to meet the same criteria required of research papers. The journal points out that the topic is "fraught with sensitivities". So neither article "proves" anything.

The article in the N.Y. Times (with all due respect it is a newspaper, not a scientific journal) reports an assertion by a Mr. Tony Frudakis, chief scietific officer of a company DNAPrint Genomics Inc. But an assertion is not only not proof, it is not even evidence. The article describes the arrest of one Derrick Todd Lee on May 27 as the alleged killer. He has been charged, but no jury has convicted him. He has not even been brought to trial. Nonetheless, Mr. Frudakis claims in the N.Y. Times article "...that is why the case ws solved two months after we ran the test for them." I think the claim of "solved" is premature, especially in the face of recent events where a number of inmates on death row in several states have been found innocent on the basis of DNA analysis. DNA can make a strong negative case that a person's DNA does not match evidence; it is very much more uncertain in making a positive correlation. Careful researchers in this area state that certain DNA analyses are not inconsistent with this or that person -- the double negative states possibility, not identity.

DNAGenomics' "test" involves determining "how much of a person's ancestry comes from each of four groups: sub-Saharan African, East Asian, Indo-European, and Native American." from which Frudakis claims to be able to estimate the individual's skin tone. Since all of these groups, roughly speaking, have dark complexions, of course any "match" will fall within that ethnic sample space. If people of Nordic ancestry were included, would there have been any differences in the DNA profiles? This is a beautiful example of the argument I call: THERE ARE NO TIGERS IN MY BACKYARD. It goes like this. I sprinkle salt in my backyard everyday to ward off invasion by man-eating tigers. You ask, "Have you ever seen any man-eating tigers, or any tigers at all, in your backyard.?" To which I respond, "No! See how well my sprinkling salt works!!" The partial definition of the human genome is a tremendous advance in science that no doubt will provide enormous advances in many fields, but the methodology can also be misused. FYI the N.Y. Times article cites two academic DNA "experts" who doubt Frudakis' claims. The example of "cold fusion" reminds us to be very careful about claims made for any invention, technology, or discovery by those who have a financial interest in the success or validity of the claim.

Vince Calder



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