Genome Mapping 2001237
Name: Xinran Maria X.
I just read several articles about the recent mapping of
the complete human genome.It said that Celera Genomics used the method
"shotgun fragmentation", and that HGP used "landmark maps". But how do
those methods exactly work?
This is going to be such a general answer that it will border on being
wrong...since the techniques are quite technical...but the shotgun method is
rather like a random chopping of a number of copies of the same page of
printed text and then deciphering the original order of the words on the
page by seeing how the different chopped up pieces overlap. NIH's method was
much more sequential...and slower.
Peter Faletra Ph.D.
Senior Science Advisor
Office of Science
Department of Energy
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Update: June 2012