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Name: Xinran Maria X.
Status: Student
Age: 13
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Question:
I just read several articles about the recent mapping of the complete human genome.It said that Celera Genomics used the method "shotgun fragmentation", and that HGP used "landmark maps". But how do those methods exactly work?



Replies:
This is going to be such a general answer that it will border on being wrong...since the techniques are quite technical...but the shotgun method is rather like a random chopping of a number of copies of the same page of printed text and then deciphering the original order of the words on the page by seeing how the different chopped up pieces overlap. NIH's method was much more sequential...and slower.

Peter Faletra Ph.D.
Senior Science Advisor
Office of Science
Department of Energy



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